Data items in the PDBX_REFERENCE_MOLECULE_DETAILS category records
textual details about small polymer molecules.
Example: 1 Actinomycin
FAM_000001 PRD_000001 1 Wikipedia ?
; Actinomycin D is primarily used as an investigative tool in cell biology to inhibit transcription. It does this by
binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase. Because it can bind
DNA duplexes, it can also interfere with DNA replication, although other chemicals such as hydroxyurea are
better suited for use in the laboratory as inhibitors of DNA synthesis.
FAM_000001 PRD_000001 2 DrugBank ?
; A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It
binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation,
termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin
FAM_000001 PRD_000003 3 DOI "DOI:10.1016/S0960-894X(98)00345-X"
; Actinomycin D, C2 and VII, cyclic peptides, inhibit Grb2 SH2 domain association with a phosphotyrosine containing
peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated
natural ligands of SH2 domain.
Key Category Items
Items in Category pdbx_reference_molecule_details